解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Nickel-titanium (NiTi, nitinol) shape memory alloy was nitrided using an original powder immersion reaction assisted coating (PIRAC) method in order to modify its surface properties. PIRAC nitriding method is based on annealing the samples in the atmosphere of highly reactive nitrogen supplied by decomposition of unst...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00368-9
更新日期:2001-07-01 00:00:00
abstract::Following an original synthesis route, we have prepared a single-component calcium phosphate apatite-like powder which settles and hardens when mixed with deionized water in an approximative 1.2 g:1 ml ratio. This paper describes the first physico-chemical studies and characterizations of the material. Observations of...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00384-7
更新日期:2001-07-01 00:00:00
abstract::The infection of an implanted prosthetic material can have serious consequences on the tissue integration of the implant and the scarring process in the host, and may even necessitate replacement of the prosthesis. This study was designed to explore the in vitro effects of Staphylococcus aureus (Sa) and Staphylococcus...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00390-2
更新日期:2001-07-01 00:00:00
abstract::The necessity of information about the inner microscopical features of low absorbing materials is one of the most important goals in the structural research field. So far, non destructive analysis have been performed using contact radiography giving the scope for great advances in the production and application of new...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00307-0
更新日期:2001-06-01 00:00:00
abstract::Bone substitutes of bovine origin are widely used for treatment of bone defects in dental and orthopedic surgery. Due to the occurrence of BSE and the new variant of Creutzfeldt Jakob Disease risks of transmitting diseases through the use of such materials need to be carefully evaluated. Risk analysis can either be ba...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00312-4
更新日期:2001-06-01 00:00:00
abstract::Particulate Bioglass is a bioactive material used in the repair of periodontal defects. This material undergoes a series of surface reactions in an aqueous environment which lead to osseointegration. The aim of this study was to determine whether these reactions exerted an antibacterial effect on a range of oral bacte...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00330-6
更新日期:2001-06-01 00:00:00
abstract::Culture of seeded osteoblastic cells in three-dimensional osteoconductive scaffolds in vitro is a promising approach to produce an osteoinductive material for repair of bone defects. However, culture of cells in scaffolds sufficiently large to bridge critical-sized defects is a challenge for tissue engineers. Diffusio...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00280-5
更新日期:2001-06-01 00:00:00
abstract::A novel class of multiblock poly(epsilon-caprolactone)-based polymers containing hydrophilic trioxyethylene segments and potentially relevant to the delivery of drugs is described in this work. L-phenylalanine residues may also be inserted into the hydrophilic blocks to generate peptide bonds susceptible to enzymatic ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00291-x
更新日期:2001-06-01 00:00:00
abstract::A biocompatible hydrogel of poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) which includes the cell-adhesive region of fibronectin Arg-Gly-Asp was synthesized and its structure, rheological and dielectric properties were characterized. The ability of a PHPMA-RGD hydrogel to promote tissue regeneration and support axon...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00354-9
更新日期:2001-05-01 00:00:00
abstract::Demineralised bone matrix (DBM) is a form of allogeneic tissue graft widely used in oral and maxillofacial procedures. There is a long history of controversy relating to the suitability of ethylene oxide gas (EtOx) as a terminal sterilisation agent for this graft, relating to its effects on the clinical performance of...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00255-6
更新日期:2001-05-01 00:00:00
abstract::The poor biocompatibility of metallic coronary stents which leads to un-satisfying restenosis rates is mainly caused by contact activation of blood cells, smooth muscle cells and endothelial cells. Mimicking a metal surface with a biocompatible coating that actively suppresses mechanisms leading to restenosis may over...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00244-1
更新日期:2001-04-01 00:00:00
abstract::The surface and bulk properties of novel methacrylate polymers prepared by gelling poly(ethyl methacrylate) (PEMA) powder with different ratios of tetrahydrofurfuryl methacrylate (THFMA) and hydroxyethyl methacrylate (HEMA) monomers were investigated. The water adsorption and desorption characteristics of these polyme...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00229-5
更新日期:2001-04-01 00:00:00
abstract::This study examined the nature of the surface presented by a machinable feldspathic porcelain and by a machinable glass-ceramic for bonding to conventional composite luting agents and measured the bond strengths which may be achieved with various surface treatments. There was no significant difference between the bond...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00294-5
更新日期:2001-04-01 00:00:00
abstract::Acute trauma or trauma associated with occlusal disturbance can produce tooth crack or fracture. Although several methods are proposed to treat the defect, however, the prognosis is generally poor. If the fusion of a tooth fracture by laser is possible, it will offer an alternative to extraction or at least serve as a...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00205-2
更新日期:2001-03-01 00:00:00
abstract::Three one-week controlled-release methadone formulations: polylactic acid microspheres (F-PLA) and poly(lactide-co-glycolide) microspheres (F-PLGA) with 24 and 30% methadone content, respectively, and an implant of 50:50 poly(lactide-co-glycolide): methadone, were evaluated in vitro and in vivo. The implant released t...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00214-3
更新日期:2001-03-01 00:00:00
abstract::Periprosthetic tissues observed at sites of loose total joint implants exhibit abundant macrophages, lymphocytes, fibroblasts and particulate debris. Macrophages phagocytose orthopaedic debris and release proinflammatory cytokines, chemokines, matrix metalloproteinases and other substances. In addition, other cell typ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00181-2
更新日期:2001-02-01 00:00:00
abstract::A series of PLA/PEO/PLA triblock copolymers was prepared by ring opening polymerization of rac-lactide in the presence of various di-hydroxyl poly (ethylene glycol)s, using CaH2 as a biocompatible initiator. Hydrogels were prepared by a phase separation method consisting of introducing small amounts of water over solu...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00192-7
更新日期:2001-02-01 00:00:00
abstract::A novel asymmetric chitosan membrane has been prepared by immersion-precipitation phase-inversion method and evaluated as wound covering. This new type of chitosan wound dressing which consists of skin surface on top-layer supported by a macroporous sponge-like sublayer was designed. The thickness of the dense skin su...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00167-8
更新日期:2001-01-01 00:00:00
abstract::There are few suitable techniques available to sterilize biodegradable polyester three-dimensional tissue engineering scaffolds because they are susceptible to degradation and/or morphological degeneration by high temperature and pressure. We used a novel polyllactide-co-glycolide) scaffold (Osteofoam) to determine th...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00136-8
更新日期:2001-01-01 00:00:00
abstract::Degradable poly(anhydride ester) implants in which the polymer backbone breaks down into salicylic acid (SA) were investigated. In this preliminary work, local release of SA from the poly(anhydride esters), thus classified as 'active polymers', on healthy bone and tissue was evaluated in vivo using a mouse model. Degr...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00118-6
更新日期:2000-12-01 00:00:00
abstract::Bioabsorbable internal fixation devices were introduced clinically in the treatment of fractures and osteotomies of the extremities at the Department of Orthopaedics and Traumatology, Helsinki University, in 1984. Since November 5, 1984, a total of 3200 patients were managed using bone or ligament fixation devices mad...
journal_title:Biomaterials
pub_type: 杂志文章,评审
doi:10.1016/s0142-9612(00)00128-9
更新日期:2000-12-01 00:00:00
abstract::It has been demonstrated that using cultured chondrocytes that have been seeded onto various biomatrices can enhance the quality of the articular cartilage repair tissue. As tissue-engineering becomes increasingly more complex there is a need to understand how a specific biomaterial may influence gene expression. In t...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00110-1
更新日期:2000-12-01 00:00:00
abstract::Procoagulant (activated) platelets provide a site for assembly of the prothrombinase complex which can rapidly convert prothrombin into thrombin (a potent inducer of clot formation). Previously, we reported that adhesion of platelets to surfaces preadsorbed with blood plasma caused them to become procoagulant. In the ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00150-2
更新日期:2000-11-01 00:00:00
abstract::Carbon fiber implants were used to fill osteochondral defects created on the articular surface of the patella of 36 rabbits, for the purpose of studying the long-term histological changes of the repair process. Six months after surgery the defect was filled by fibrous tissue, where the superficial area was organized p...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00144-7
更新日期:2000-11-01 00:00:00
abstract::Gelatin and dextran were blended and crosslinked to form enzymatically degradable interpenetrating polymeric networks (IPNs) as materials for degradable implants. Several crosslinking methods were investigated including treatment with glyceraldehyde, thermal hardening, and chelation of dextran by divalent metal cation...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00057-0
更新日期:2000-10-01 00:00:00
abstract::Neurotrophic factors therapy requires their precise delivery to the targeted neuronal population. For this purpose, a wide range of strategies have been developed, and among them the stereotaxic implantation of biodegradable microparticles. To assess the in vivo activity of NGF-releasing PLGA microspheres, unloaded an...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00141-1
更新日期:2000-10-01 00:00:00
abstract::The rate of change of pH of aqueous lactic acid at pH 4.2-4.5 (i.e. a little below that of active caries in vivo) in contact with disks of various commercial glass-ionomer cements has been determined in two configurations. In the first of them, a thin film set-up, 20 microl of solution was spread across the surface of...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00085-5
更新日期:2000-10-01 00:00:00
abstract::6-O-Carboxymethylchitin (CM-chitin) was partially deacetylated by alkaline treatment, and the 30% deacetylated product was named CM-DA30 and used for the preparation of microspheres. An aqueous solution of CM-DA30 was added to hexane containing 1% (w/w) sorbitan sesquioleate and emulsified by stirring and sonication, ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00069-7
更新日期:2000-09-01 00:00:00
abstract::The contraction of connective tissue cells may facilitate their production and maintenance of extracellular matrix architecture and can benefit healing through wound closure. However, aberrant cell contraction can result in pathological contracture. Implants may stimulate this process leading to contracture of the sur...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00062-4
更新日期:2000-09-01 00:00:00
abstract::The water-soluble, low toxic and less biodegradable chitosan derivative N-succinyl-chitosan (Suc-chitosan) was investigated for body distribution and urinary excretion on a long-time scale (24-72 h after i.v. injection) using a fluorescein-labeling technique. Fluorescein isothiocyanate (FITC)-labeled Suc-chitosan (Suc...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00044-2
更新日期:2000-08-01 00:00:00
abstract::Biocompatibility and tissue regenerating capacity are essential characteristics in the design of collagenous biomaterials for tissue engineering. Attachment of glycosaminoglycans (GAGs) to collagen may add to these characteristics by creating an appropriate micro-environment. In this study, porous type I collagen matr...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00052-1
更新日期:2000-08-01 00:00:00
abstract::Membranes based on mechanically supported poly(vinyl alcohol) (PVA) hydrogels with mesh-size asymmetry were developed for potential application in biohybrid artificial organs. The pores of cellulose ester microfiltration membranes were impregnated with a PVA solution, which was lightly crosslinked with glutaraldehyde ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00022-3
更新日期:2000-07-01 00:00:00
abstract::Magnetic microcarrier particles useful for delivering chemotherapeutic drug molecules are described. The particles are formed by joint deformation of iron and carbon in a ball mill. Physical, chemical, and functional characterization has been carried out on the particles. Physical characteristics include microscopy, p...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00006-5
更新日期:2000-07-01 00:00:00
abstract::The objective of this study was to investigate the moisture absorption, physical-mechanical and bioadhesive properties of hot-melt extruded hydroxypropylcellulose (HPC) films containing polymer additives. These additives included polyethylene glycol (PEG) 5%, polycarbophil 5%, carbomer 5%, Eudragit E-100 5%, and sodiu...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00046-6
更新日期:2000-07-01 00:00:00
abstract::The commercial availability of peptides and proteins and their advantages as therapeutic agents have been the basis for tremendous efforts in designing delivery systems for such agents. The protection of these agents from biological fluids and physiological interactions is crucial for the treatment efficacy. One such ...
journal_title:Biomaterials
pub_type: 杂志文章,评审
doi:10.1016/s0142-9612(00)00011-9
更新日期:2000-06-01 00:00:00
abstract::The in vivo properties of a new kind of calcium phosphate cement were investigated in this study. Calcium phosphate cement was implanted as paste into femoral bone and dorsal muscle of dogs for 3 and 6 months, and as prehardened form into thigh muscles of dogs for 1, 2 and 6 months. Histology was performed on thin un-...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00016-8
更新日期:2000-06-01 00:00:00
abstract::Well-characterised human osteoblastic bone marrow cell cultures are a useful in vitro tool to analyse bone tissue/biomaterials interactions. In this work, human bone marrow was cultured in experimental conditions described to favour osteoblastic differentiation and, serially passaged cells were cultured in two widely ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00284-7
更新日期:2000-06-01 00:00:00
abstract::Endothelial cells derived from the bovine pulmonary artery (line CPAE, CCL 209, American Tissue Culture Collection, Rockville, MD, USA) were cultured on pristine or fluorine ion-irradiated polystyrene (5 x 10(12) or 5 x 10(14) F ions/cm2, 150 keV). At 24-h post-seeding interval, the number of cells which adhered to th...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00009-0
更新日期:2000-06-01 00:00:00
abstract::The effect of inclusion of an immobilization matrix and the capsule membrane permeability on the viability, metabolic activity, and proliferation of encapsulated HEK cells was investigated in vitro. In the absence of a matrix, a particular transfected HEK cell line formed a single aggregate in the core of the poly(hyd...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00251-3
更新日期:2000-05-01 00:00:00
abstract::Distearoylphophatidylcholine (DSPC) mixed with various mole percentages of polyethylene oxide (number average molecular weight 2000)-grafted distearoylphosphatidylethanolamine (PEO2000-DSPE) were deposited on DSPE-coated quartz surfaces by the Langmuir-Blodgett deposition. Structural transitions in PEO2000 from pancak...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(00)00004-1
更新日期:2000-05-01 00:00:00